GUILLAIN-BARRE SINDROMI VA UNI TASHXISLASHGA ZAMONAVIY YONDASHUV
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Abstract
Guillain-Barre (Giyen-Barre) sindromi (GBS)-periferik nerv sistemasining yallig‘lanish kasalligi bo‘lib, o‘tkir bo‘shashgan falajlikning eng keng tarqalgan sababi bo‘lib, yillik global kasallanish taxmin erkaklarda ayollarga qaraganda tez-tez uchraydi va kasallanish bemor yoshi kattalashishi bilan ortadi, ammo barcha yosh guruhlariga ta’sir qilishi mumkin .GBS bilan og‘rigan bemorlar odatda oyoqlarda qo‘llar va kranial mushaklarga o‘tadigan zaiflik va hissiy belgilar bilan namoyon bo‘ladilar, garchi kasallikning klinik ko‘rinishi geterogen bo‘lsa-da va bir nechta aniq klinik variantlar mavjud. GBS patogenezi to‘liq tushunilmagan bo‘lsa-da, periferik nervlarning shikastlanishiga olib keladigan infeksiyalarga noadekvat immun javobidan kelib chiqadi deb taxmin qilinadi.GBS bilan og‘rigan bemorlarning kichik guruhida gangliozidlarga qarshi antitanalar topiladi, ular aksolemma va periferik nervlarning boshqa tarkibiy qismlarida yuqori zichlikda joylashganbo‘ladi. GBSkasallikni qo‘zg‘atadigan yuqumli kasalliklar epidemiyasi paytida ortishi mumkin.
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